UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle
نویسندگان
چکیده
منابع مشابه
Aging of Skeletal Muscle Fibers
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional cap...
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We propose highly aligned skeletal muscle fibers (Fig.1). We found that the textiles of a fibrin hydrogel fiber are highly orientated to the the longitudinal direction of the fiber by using a micro fluidic channel of a micro glass capillary tube. We also confirmed that the seeded skeletal muscle cells, C2C12, migrated into the fiber and aligned to the fiber direction without any complex lithogr...
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Muscle fibrosis is a common Orthopaedic problem that results from tissue trauma, degeneration, neurotoxin injection and disuse. However, the interaction between skeletal muscle cells and the components of the extracellular matrix (ECM) that results in development of fibrotic tissue is not well understood. In this study, we have exploited the fact that the skeletal muscle intermediate filament p...
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The skeletal muscle fibers of mammals have been histochemically classified into two types, red and white (DUBOWITZ and PEARSE 1960, NACHMIAS and PADYKULA 1958), or three types (OGATA 1958, STEIN and PADYKULA 1962, OGATA and MORI 1964). The definite arrangement of various types of fibers within a muscle was reported by ROMANUL (1964). Although it has been reported that skeletal muscles are divid...
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BACKGROUND Insulin resistance triggered by excess fat is a key pathogenic factor that promotes type 2 diabetes. Understanding molecular mechanisms of insulin resistance may lead to the identification of a novel therapeutic target for type 2 diabetes. AMPD1, an isoform of AMP deaminase (AMPD), is suggested to play roles in the regulation of glucose metabolism through controlling AMP-activated pr...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2019
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2019.116699